Jun 01, 2013 DMG — When TMG lets go of one of its methyl groups, it deposits a substance called dimethylglycine or DMG. This is a B-complex vitamin and is used to improve speech and behavior in autism, for attention deficit-hyperactivity disorder (ADHD), epilepsy and neurological function. I've been using TMG and Methylfolate for extended periods of time on and off for about 2 years now. Both seem to be somewhat useful for energy, mood and sleep quality in small amounts (150 mcg methylfolate and/or 250 mg tmg) but at the amounts I was recommended, Methylfolate made me restless and manic while higher amounts of TMG.
Alternative names: Anhydrous Betaine or simply Betaine.
An extract from sugar beets, TMG is a natural polysaccharide and a good source of methyl groups that promotes healthier levels of the powerful pro-oxidant and free radical generator homocysteine. Homocysteine is a toxic end product of the metabolism (methylation) of methionine (an essential amino acid) and is now known to be a leading cause of heart and artery disease.
Dmg Supplement Vs Tmg Performance
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Dimethylglycine (or DMG for short) is a derivative of the amino acid glycine — a building block essential for creating protein. It is present in the cells of all plants and animals, specifically in small amounts of grains and meat. Your body will produce DMG when metabolizing choline into glycine. 'Dosage of DMG should be reduced if you are taking TMG, B vitamins, SAMe, and/or choline, since all these nutrients have overlapping functions and can be methyl donors.' Depending on the specific health problem, the recommended dosage of DMG can range from 50 milligrams to more than 1,000 milligrams daily.
TMG is a byproduct of sugar beet processing and is a known methyl donor. Through methyl transfers, betaine is derived from choline and subsequent reactions convert betaine to dimethylglycine. Betaine may influence neurological function indirectly via 5-adenosylmethionine synthesis. Animal studies have demonstrated that supplementary intake of betaine had a 2- to 5-fold increase in SAM concentrations. Hyland et al reported increased SAM concentrations to near normal in a patient suffering from 5,10-methylenetetrahydrofolate reductase (an enzyme involved in the regeneration of methionine) deficiency where initial SAM concentration were undetectable.
Methylation reactions and how they relate to the prevention of many diseases such as cancer, heart disease, liver disease and neurological disorders are a growing area of interest for researchers.
Source
TMG is in available in powdered form, and is found in many over-the-counter preparations in health food stores.
NOTE: An inexpensive variety is Betaine HCL which acts as a stomach acidifier and is not practical due to stomach irritation at the doses required to enhance methylation metabolism.
Function; Why it is Recommended
In the liver, TMG transfers one of its three methyl groups to homocysteine, which is then converted into the useful amino acidmethionine.
When methylation is working properly, homocysteine is quickly converted back to methionine which is then converted to SAMe (S-adenosylmethionine), which protects the liver and is a natural antidepressant. [2][3] SAMe then acts as a methyl donor for DNA: when attached to DNA, methyl groups appear protective, preventing mutated genes from expressing themselves. [4] It may improve health, reduce the risk of genetically induced cancers, and slow cellular aging. Factors that decrease methylation include smoking, alcohol consumption, high fat diets and birth control pills.
Multiple studies have demonstrated that medium to high levels of plasma homocysteine are associated with increased risk of heart disease, cerebrovascular disease and peripheral artery disease. In one study, daily treatment with TMG, folic acid and choline normalized homocysteine levels in 17 of 19 patients. Korg pa1x pro download. [1] TMG lowers homocysteine levels with and without vitamins B12, B6 and folic acid.
Along with cofactors such as vitamins B6, B12 and Folic Acid, TMG is part of a chemical contingent in the body that works against cancer, heart and neurological diseases, and nearly every age-related disorder.
TMG is a versatile nutrient and provides an intermediary metabolite that can enable a person or animal to function at more optimum mental and physical levels. It aids the body in overcoming a number of adverse health conditions, and is an intricate part of human metabolism. DMG (TMG's metabolite) has been used as a nutritional supplement for over 25 years. In a broad sense, TMG protects the body from many forms of physical, metabolic and environmental stress.
Applications include:
- Immune modulation: Improves antibody response, enhances B- and T-cell function, and regulates cytokines.
- Viral/bacterial infections: Enhances immune response.
- Cardiovascular: Reduces cholesterol and triglyceride levels, helps eliminate hypoxia, improves coronary circulation, decreases angina pain.
- Athletic performance: Enhances endurance, improves oxygen utilization, reduces lactic acid buildup, improves muscle recovery.
- Autism/epilepsy: Improves verbal communication/social interaction/lethargy, may reduce seizures.
- Chronic fatigue syndrome: Greater mental alertness and energy, improves immune dysfunction.
- Melanoma: Anti-tumor activity, prevents metastasis.
- Lupus (SLE): Reduces antinuclear antibodies, modulates cytokine production.
- Contributes to DNA stability: As a methyl donor supplement, it helps protect cellular DNA from mutation.
- Liver detoxification
- Brain neurotransmitter production
- Lowering homocysteine levels naturally: Thereby lowers risk of heart and vascular disease.
TMG supplementation may sometimes produce hyperactivity in autistic children. Folic acid appears to help neutralize this effect at one or two 800mcg tablets. [Autism Res Rev Int 10( 3): 7, 1996]
Instructions
The usual TMG dose is 500 to 1,000mg per day – roughly equivalent to what a diet high in broccoli, spinach or beets would provide.
References & Further Information
(1) Dudman, N.P., et al. 'Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy and enzymology,' Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993
(2) Dudman, N. 'Disordered methionine/homocysteine metabolism in premature vascular disease,' Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993
(3) Kishi, T. 'Effect of betaine on s-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy' J Inherited Metabolic Disease 17(5): 560-5, 1994
(4) Cooney, C. 'Are somatic cells inherently deficient in methylation metabolism?' Growth, Development & Aging 57(4): 261-73, 1993
Dmg Supplement Vs Tmg Manufacturing
Sponsored by DaVinci Laboratories
Although N N-Dimethylglycine (DMG) has been on the health scene for over forty years, few physicians were aware of its wide range of benefits until recently.
First introduced in the 1970s, the supplement is now reaching the mainstream of natural medicine. The best way physicians can get to know and understand this product is by experiencing its benefits in their own practices, according to Roger Kendall, PhD, one of the world's leading authorities on DMG.
Dimethylglycine has a broad role as a vital 'anti-stress' nutrient in advancing optimal health and well-being. It helps the body respond to environmental, physical, mental, and emotional stressors affecting human health, while also supporting immune, cardiovascular, and brain functions.
7 HEALTH BENEFITS OF DMG
1. Enhancing Metabolic Function
Jerzy Meduski, MD, at the University of Southern California's School of Medicine in Los Angeles called DMG a metabolic enhancer. In his research, Meduski found DMG made cells function at a higher efficiency, a 'super-catalyst' that seems to boost the metabolic pathways.
When taken as a supplement, DMG aids in the production of metabolic intermediates – building blocks used to create hormones, key vitamins, and nucleic acids for DNA and RNA repair. DMG gives up its pieces metabolically in the process. In the words of Dr. Kendall, 'Dimethylglycine works by falling apart, so you don't have to.'
2. Supporting the Body under Stress
DMG helps the body adapt to environmental, physical, mental, or emotional stressors. When the body continues to produce stress hormones over an extended period of time, nutrient stores can become depleted. Fatigue sets in. Living under constant stress can lead to degeneration, disease, and impaired immune and digestive function. DMG supports the body under stressful conditions by improving immune response, enhancing energy, and supporting mental alertness.
3. Finding Balance
DMG is an adaptogen – a natural substance helping the body's systems establish balance and homeostasis. In addition to helping the body regulate and manage stress, it improves efficiency in how cells function, whether they're in the brain, heart, kidneys, or liver. Kendall's studies show DMG can positively impact just about all the different organ systems and metabolic pathways in the body involved in his research.
4. Enhancing Energy Levels
DMG is valuable in sports medicine practices for athletes and patients seeking greater endurance because it improves muscle recovery after strenuous activity. The supplement supports lung function and oxygen exchange, reducing fatigue and increasing energy. It also encourages efficient energy production and drives cellular reactions, so the body works more effectively.
In the liver, TMG transfers one of its three methyl groups to homocysteine, which is then converted into the useful amino acidmethionine.
When methylation is working properly, homocysteine is quickly converted back to methionine which is then converted to SAMe (S-adenosylmethionine), which protects the liver and is a natural antidepressant. [2][3] SAMe then acts as a methyl donor for DNA: when attached to DNA, methyl groups appear protective, preventing mutated genes from expressing themselves. [4] It may improve health, reduce the risk of genetically induced cancers, and slow cellular aging. Factors that decrease methylation include smoking, alcohol consumption, high fat diets and birth control pills.
Multiple studies have demonstrated that medium to high levels of plasma homocysteine are associated with increased risk of heart disease, cerebrovascular disease and peripheral artery disease. In one study, daily treatment with TMG, folic acid and choline normalized homocysteine levels in 17 of 19 patients. Korg pa1x pro download. [1] TMG lowers homocysteine levels with and without vitamins B12, B6 and folic acid.
Along with cofactors such as vitamins B6, B12 and Folic Acid, TMG is part of a chemical contingent in the body that works against cancer, heart and neurological diseases, and nearly every age-related disorder.
TMG is a versatile nutrient and provides an intermediary metabolite that can enable a person or animal to function at more optimum mental and physical levels. It aids the body in overcoming a number of adverse health conditions, and is an intricate part of human metabolism. DMG (TMG's metabolite) has been used as a nutritional supplement for over 25 years. In a broad sense, TMG protects the body from many forms of physical, metabolic and environmental stress.
Applications include:
- Immune modulation: Improves antibody response, enhances B- and T-cell function, and regulates cytokines.
- Viral/bacterial infections: Enhances immune response.
- Cardiovascular: Reduces cholesterol and triglyceride levels, helps eliminate hypoxia, improves coronary circulation, decreases angina pain.
- Athletic performance: Enhances endurance, improves oxygen utilization, reduces lactic acid buildup, improves muscle recovery.
- Autism/epilepsy: Improves verbal communication/social interaction/lethargy, may reduce seizures.
- Chronic fatigue syndrome: Greater mental alertness and energy, improves immune dysfunction.
- Melanoma: Anti-tumor activity, prevents metastasis.
- Lupus (SLE): Reduces antinuclear antibodies, modulates cytokine production.
- Contributes to DNA stability: As a methyl donor supplement, it helps protect cellular DNA from mutation.
- Liver detoxification
- Brain neurotransmitter production
- Lowering homocysteine levels naturally: Thereby lowers risk of heart and vascular disease.
TMG supplementation may sometimes produce hyperactivity in autistic children. Folic acid appears to help neutralize this effect at one or two 800mcg tablets. [Autism Res Rev Int 10( 3): 7, 1996]
Instructions
The usual TMG dose is 500 to 1,000mg per day – roughly equivalent to what a diet high in broccoli, spinach or beets would provide.
References & Further Information
(1) Dudman, N.P., et al. 'Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy and enzymology,' Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993
(2) Dudman, N. 'Disordered methionine/homocysteine metabolism in premature vascular disease,' Arteriosclerosis and Thrombosis 13(9): 1253-60, 1993
(3) Kishi, T. 'Effect of betaine on s-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy' J Inherited Metabolic Disease 17(5): 560-5, 1994
(4) Cooney, C. 'Are somatic cells inherently deficient in methylation metabolism?' Growth, Development & Aging 57(4): 261-73, 1993
Dmg Supplement Vs Tmg Manufacturing
Sponsored by DaVinci Laboratories
Although N N-Dimethylglycine (DMG) has been on the health scene for over forty years, few physicians were aware of its wide range of benefits until recently.
First introduced in the 1970s, the supplement is now reaching the mainstream of natural medicine. The best way physicians can get to know and understand this product is by experiencing its benefits in their own practices, according to Roger Kendall, PhD, one of the world's leading authorities on DMG.
Dimethylglycine has a broad role as a vital 'anti-stress' nutrient in advancing optimal health and well-being. It helps the body respond to environmental, physical, mental, and emotional stressors affecting human health, while also supporting immune, cardiovascular, and brain functions.
7 HEALTH BENEFITS OF DMG
1. Enhancing Metabolic Function
Jerzy Meduski, MD, at the University of Southern California's School of Medicine in Los Angeles called DMG a metabolic enhancer. In his research, Meduski found DMG made cells function at a higher efficiency, a 'super-catalyst' that seems to boost the metabolic pathways.
When taken as a supplement, DMG aids in the production of metabolic intermediates – building blocks used to create hormones, key vitamins, and nucleic acids for DNA and RNA repair. DMG gives up its pieces metabolically in the process. In the words of Dr. Kendall, 'Dimethylglycine works by falling apart, so you don't have to.'
2. Supporting the Body under Stress
DMG helps the body adapt to environmental, physical, mental, or emotional stressors. When the body continues to produce stress hormones over an extended period of time, nutrient stores can become depleted. Fatigue sets in. Living under constant stress can lead to degeneration, disease, and impaired immune and digestive function. DMG supports the body under stressful conditions by improving immune response, enhancing energy, and supporting mental alertness.
3. Finding Balance
DMG is an adaptogen – a natural substance helping the body's systems establish balance and homeostasis. In addition to helping the body regulate and manage stress, it improves efficiency in how cells function, whether they're in the brain, heart, kidneys, or liver. Kendall's studies show DMG can positively impact just about all the different organ systems and metabolic pathways in the body involved in his research.
4. Enhancing Energy Levels
DMG is valuable in sports medicine practices for athletes and patients seeking greater endurance because it improves muscle recovery after strenuous activity. The supplement supports lung function and oxygen exchange, reducing fatigue and increasing energy. It also encourages efficient energy production and drives cellular reactions, so the body works more effectively.
5. Managing Cardiovascular and Heart Health
DMG aids in reducing homocysteine levels, a risk factor in cardiovascular disease. It also has an impact on normalizing cholesterol and triglyceride levels. Additionally, it protects the body against hypertension and high blood pressure while improving circulation.
6. Boosting Brain Function
DMG supports the body's production of creatine and phosphocreatine, which fuel energy within the brain and curb mental fatigue. Because the supplement can cross the blood-brain barrier, it helps maximize brain function, bolster brain acuity, and improve mental focus.
Studies also show benefits for people with autism. Kendall's work with Bernard Rimland, PhD at the Autism Research Institute led to positive reports of improved communication, eye contact, sleep patterns, immune function, and general social interactions.
7. Bolstering Immune Function
DMG holds special interest for patients with immune deficiencies. This tremendous resistance builder enhances the body's natural protection against bacterial, fungal, and viral diseases.
DMG supports immune function by contributing to methylation, a process by which methyl groups, each composed of one carbon atom and three hydrogen atoms, are transferred from one substance to another. These groups are essential to cell functions throughout the body. In the immune system, methylation is important in the production of antibodies and cytokine components.1
Integrating DMG into Your Practice
Kendall suggests physicians integrate DMG in their practices by recommending it to the patients most likely to experience benefits – such as older patients, who enjoyed improved metabolism and energy in his research – and by asking them to track their results. Doctors can offer DMG to patients suffering from brain dysfunction, cardiovascular issues, immune system deficiency, or a need to detoxify.
Patients often want to continue use after experiencing the health benefits, like feeling more energized. It's really just a matter of tracking the results for each patient once they try it.
Kendall recommends getting started by selecting ten patients with varied conditions and putting them on a regular program, as described in his book, Building Wellness with DMG, co-authored with Adena Therrien. The book provides guidance for physicians using DMG in their practices, including specific dosage recommendations. It also serves as a well-documented reference for lay people and physicians who want to know more about the supplement in general.
The Future of DMG
Dmg Tmg Difference
With the number of Americans age 65 and older estimated to grow to over 98 million by 2060, DMG will become increasingly important to sustaining mental and physical performance and helping the body overcome degenerative conditions.
As the body begins to wear down over time, Kendall says the key is to live longer well, rather than live longer poorly. DMG can be thought of as anti-aging in that it allows the body to function at higher efficiency for longer periods of time. This will become critical as people delay retirement and work later into life.
We also just experienced one of the roughest flu seasons in recent memory, and as new strains of the virus develop, a stronger immune system will be more important than ever.
While not technically a vitamin, DMG is the nutrient behind what was formerly known as Vitamin B-15. Taken every day, it can raise efficiency and metabolic function to a higher caliber. It optimizes physical and mental performance, protects against disease, enhances heart function, and supports mental function.
In other words, it's essential for building optimum wellness and vitality.
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